Deletion of the Transforming Growth Factor β Receptor Type II Gene in Articular Chondrocytes Leads to a Progressive Osteoarthritis-like Phenotype in Mice

OBJECTIVE: While transforming growth factor β (TGFβ) signaling plays a critical role in chondrocyte metabolism, the TGFβ signaling pathways and target genes involved in cartilage homeostasis and the development of osteoarthritis (OA) remain unclear. Using an in vitro cell culture method and an in vi...

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Detalhes bibliográficos
Main Authors: Shen, Jie, Li, Jia, Wang, Baoli, Jin, Hongting, Wang, Meina, Zhang, Yejia, Yang, Yunzhi, Im, Hee-Jeong, O’Keefe, Regis, Chen, Di
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3928444/
https://ncbi.nlm.nih.gov/pubmed/23982761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.38122
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