Sequence specific cleavage of DNA by the antitumor antibiotics neocarzinostatin and bleomycin.

We have investigated the sites of DNA damage by the antitumor antibiotics neocarzinostatin and bleomycin by using a 5'-end-labeled DNA fragment of defined sequence as a substrate. At the high drug concentrations used here, neocarzinostatin creates single-strand breaks in DNA at positions of ade...

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Detalles Bibliográficos
Main Authors: D'Andrea, A D, Haseltine, W A
Formato: Artigo
Idioma:Inglês
Publicado: 1978
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC392834/
https://ncbi.nlm.nih.gov/pubmed/80799
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