DNA structure influences sequence specific cleavage by bleomycin.
We have examined the cleavage of several synthetic DNA sequences by iron(II)-bleomycin. We find that, although bleomycin cuts mixed sequence DNAs with a preference for GC = GT > GA >> GG, it efficiently cleaves regions of (AT)n cutting exclusively at ApT, not TpA. Isolated ApT steps show very little...
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| Publicado no: | Nucleic Acids Res |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
1993
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| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC309580/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7687342/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/21.11.2549 |
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