Efficient pH-independent sequence-specific DNA binding by pseudoisocytosine-containing bis-PNA.

The synthesis and DNA binding properties of bis-PNA (peptide nucleic acid) are reported. Two PNA segments each of seven nucleobases in length were connected in a continuous synthesis via a flexible linker composed of three 8-amino-3,6-dioxaoctanoic acid units. The sequence of the first strand was TC...

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Main Authors: Egholm, M, Christensen, L, Dueholm, K L, Buchardt, O, Coull, J, Nielsen, P E
Format: Artigo
Sprog:Inglês
Udgivet: 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC306657/
https://ncbi.nlm.nih.gov/pubmed/7862524
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