The mTOR Pathway Controls Cell Proliferation by Regulating the FoxO3a Transcription Factor via SGK1 Kinase

The mechanistic target of rapamycin (mTOR) functions as a component of two large complexes, mTORC1 and mTORC2, which play crucial roles in regulating cell growth and homeostasis. However, the molecular mechanisms by which mTOR controls cell proliferation remain elusive. Here we show that the FoxO3a...

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Main Authors: Mori, Shunsuke, Nada, Shigeyuki, Kimura, Hironobu, Tajima, Shoji, Takahashi, Yusuke, Kitamura, Ayaka, Oneyama, Chitose, Okada, Masato
格式: Artigo
語言:Inglês
出版: Public Library of Science 2014
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3928304/
https://ncbi.nlm.nih.gov/pubmed/24558442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088891
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