SGK1 inhibition induces autophagy-dependent apoptosis via the mTOR-Foxo3a pathway

BACKGROUND: Although inhibition of SGK1 has been shown to delay cancer progression, the underlying mechanisms have not yet been elucidated. METHODS: We investigated the cellular responses to GSK650394 treatment and SGK1 silencing (or overexpression) in human prostate cancer (PCa) cell lines and PC3...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Liu, Weiwei, Wang, Xuchu, Liu, Zhenping, Wang, Yiyun, Yin, Binbin, Yu, Pan, Duan, Xiuzhi, Liao, Zhaoping, Chen, Yuhua, Liu, Chunhua, Li, Xiang, Dai, Yibei, Tao, Zhihua
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5674106/
https://ncbi.nlm.nih.gov/pubmed/29017179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.293
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