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Down-regulation of the Tumor Suppressor C-terminal Src Kinase (Csk)-binding Protein (Cbp)/PAG1 Is Mediated by Epigenetic Histone Modifications via the Mitogen-activated Protein Kinase (MAPK)/Phosphatidylinositol 3-Kinase (PI3K) Pathway

The transmembrane adaptor protein Cbp (or PAG1) functions as a suppressor of Src-mediated tumor progression by promoting the inactivation of Src. The expression of Cbp is down-regulated in Src-transformed cells and in various human cancer cells, suggesting a potential role for Cbp as a tumor suppres...

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Библиографические подробности
Главные авторы: Suzuki, Kei, Oneyama, Chitose, Kimura, Hironobu, Tajima, Shoji, Okada, Masato
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2011
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3091178/
https://ncbi.nlm.nih.gov/pubmed/21388951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.195362
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