A Novel Pathway Links Oxidative Stress to Loss of Insulin Growth Factor-2 (IGF2) Imprinting through NF-κB Activation

Genomic imprinting is the allele-specific expression of a gene based on parental origin. Loss of imprinting(LOI) of Insulin-like Growth Factor 2 (IGF2) during aging is important in tumorigenesis, yet the regulatory mechanisms driving this event are largely unknown. In this study oxidative stress, me...

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Bibliografische gegevens
Hoofdauteurs: Yang, Bing, Wagner, Jennifer, Damaschke, Nathan, Yao, Tianyu, Wuerzberger-Davis, Shelly M., Lee, Moon-Hee, Svaren, John, Miyamoto, Shigeki, Jarrard, David F.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2014
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3928145/
https://ncbi.nlm.nih.gov/pubmed/24558376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088052
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