IPO3-mediated Nonclassical Nuclear Import of NF-κB Essential Modulator (NEMO) Drives DNA Damage-dependent NF-κB Activation

Activation of IκB kinase (IKK) and NF-κB by genotoxic stresses modulates apoptotic responses and production of inflammatory mediators, thereby contributing to therapy resistance and premature aging. We previously reported that genotoxic agents induce nuclear localization of NF-κB essential modulator...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Hwang, Byounghoon, McCool, Kevin, Wan, Jun, Wuerzberger-Davis, Shelly M., Young, Edmond W. K., Choi, Eun Young, Cingolani, Gino, Weaver, Beth A., Miyamoto, Shigeki
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505044/
https://ncbi.nlm.nih.gov/pubmed/26060253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.645960
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge