Nerve growth factor metabolic dysfunction in Down’s syndrome brains

Basal forebrain cholinergic neurons play a key role in cognition. This neuronal system is highly dependent on NGF for its synaptic integrity and the phenotypic maintenance of its cell bodies. Basal forebrain cholinergic neurons progressively degenerate in Alzheimer’s disease and Down’s syndrome, and...

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Bibliographische Detailangaben
Hauptverfasser: Iulita, M. Florencia, Do Carmo, Sonia, Ower, Alison K., Fortress, Ashley M., Aguilar, Lisi Flores, Hanna, Michael, Wisniewski, Thomas, Granholm, Ann-Charlotte, Buhusi, Mona, Busciglio, Jorge, Cuello, A. Claudio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3927704/
https://ncbi.nlm.nih.gov/pubmed/24519975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awt372
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