Nerve growth factor metabolic dysfunction in Down’s syndrome brains

Basal forebrain cholinergic neurons play a key role in cognition. This neuronal system is highly dependent on NGF for its synaptic integrity and the phenotypic maintenance of its cell bodies. Basal forebrain cholinergic neurons progressively degenerate in Alzheimer’s disease and Down’s syndrome, and...

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Detalhes bibliográficos
Main Authors: Iulita, M. Florencia, Do Carmo, Sonia, Ower, Alison K., Fortress, Ashley M., Aguilar, Lisi Flores, Hanna, Michael, Wisniewski, Thomas, Granholm, Ann-Charlotte, Buhusi, Mona, Busciglio, Jorge, Cuello, A. Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3927704/
https://ncbi.nlm.nih.gov/pubmed/24519975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awt372
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