The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains.

Ítems similars

• The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions.
  per: Serra-Pagès, C, et al.
  Publicat: (1995)
• Function and regulation of the Rho guanine nucleotide exchange factor Trio
  per: Schmidt, Susanne, et al.
  Publicat: (2014)
• The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1.
  per: Pulido, R, et al.
  Publicat: (1995)
• Mutations specific to the Rac-GEF domain of TRIO cause intellectual disability and microcephaly
  per: Pengelly, Reuben J, et al.
  Publicat: (2016)
• Supervillin Binds the Rac/Rho-GEF Trio and Increases Trio-mediated Rac1 Activation
  per: Son, Kyonghee, et al.
  Publicat: (2015)