The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains.

rho-like GTP binding proteins play an essential role in regulating cell growth and actin polymerization. These molecular switches are positively regulated by guanine nucleotide exchange factors (GEFs) that promote the exchange of GDP for GTP. Using the interaction-trap assay to identify candidate pr...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Debant, A, Serra-Pagès, C, Seipel, K, O'Brien, S, Tang, M, Park, S H, Streuli, M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39269/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8643598/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.11.5466
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