MLH1-Silenced and Non-Silenced Subgroups of Hypermutated Colorectal Carcinomas Have Distinct Mutational Landscapes

Approximately 15% of colorectal carcinomas (CRC) exhibit a hypermutated genotype accompanied by high levels of microsatellite instability (MSI-H) and defects in DNA mismatch repair. These tumors, unlike the majority of colorectal carcinomas, are often diploid, exhibit frequent epigenetic silencing o...

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Main Authors: Donehower, Lawrence A., Creighton, Chad J., Schultz, Nikolaus, Shinbrot, Eve, Chang, Kyle, Gunaratne, Preethi H., Muzny, Donna, Sander, Chris, Hamilton, Stanley R., Gibbs, Richard A., Wheeler, David
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926301/
https://ncbi.nlm.nih.gov/pubmed/22899370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4087
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