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Blocking SDF-1α/CXCR4 downregulates PDGF-B and inhibits bone marrow derived pericyte differentiation and tumor vascular expansion in Ewing’s tumors
Bone marrow cells (BMCs) are critical to the expansion of the tumor vessel network that supports Ewing’s sarcoma growth. BMCs migrate to the tumor and differentiate into endothelial cells and pericytes. We recently demonstrated that stromal derived growth factor 1α (SDF-1α) regulates platelet derive...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3926209/ https://ncbi.nlm.nih.gov/pubmed/24282276 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-0447 |
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