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DETECTING STATISTICAL INTERACTION BETWEEN SOMATIC MUTATIONAL EVENTS AND GERMLINE VARIATION FROM NEXT-GENERATION SEQUENCE DATA
The two-hit model of carcinogenesis provides a valuable framework for understanding the role of DNA repair and tumor suppressor genes in cancer development and progression. Under this model, tumor development can initiate from a single somatic mutation in individuals that inherit an inactivating ger...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3926123/ https://ncbi.nlm.nih.gov/pubmed/24297533 |
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