BRCA somatic and germline mutation detection in paraffin embedded ovarian cancers by next-generation sequencing

BRCA mutated ovarian cancers respond better to platinum-based therapy and to the recently approved PARP-inhibitors. There is the need for efficient and timely methods to detect both somatic and germline mutations using formalin-fixed paraffin-embedded (FFPE) tissues and commercially available techno...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Mafficini, Andrea, Simbolo, Michele, Parisi, Alice, Rusev, Borislav, Luchini, Claudio, Cataldo, Ivana, Piazzola, Elena, Sperandio, Nicola, Turri, Giona, Franchi, Massimo, Tortora, Giampaolo, Bovo, Chiara, Lawlor, Rita T., Scarpa, Aldo
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
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Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811444/
https://ncbi.nlm.nih.gov/pubmed/26745875
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