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Estimating Exceptionally Rare Germline and Somatic Mutation Frequencies via Next Generation Sequencing
We used targeted next generation deep-sequencing (Safe Sequencing System) to measure ultra-rare de novo mutation frequencies in the human male germline by attaching a unique identifier code to each target DNA molecule. Segments from three different human genes (FGFR3, MECP2 and PTPN11) were studied....
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4920415/ https://ncbi.nlm.nih.gov/pubmed/27341568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0158340 |
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