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CD28 and CD3 have complementary roles in T-cell traction forces

Mechanical forces have key roles in regulating activation of T cells and coordination of the adaptive immune response. A recent example is the ability of T cells to sense the rigidity of an underlying substrate through the T-cell receptor (TCR) coreceptor CD3 and CD28, a costimulation signal essenti...

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Autors principals: Bashour, Keenan T., Gondarenko, Alexander, Chen, Haoqian, Shen, Keyue, Liu, Xin, Huse, Morgan, Hone, James C., Kam, Lance C.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926067/
https://ncbi.nlm.nih.gov/pubmed/24469820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1315606111
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