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The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

Given the trillions of microbes that inhabit the mammalian intestines, the host immune system must constantly maintain a balance between tolerance to commensals and immunity against pathogens to avoid unnecessary immune responses against otherwise harmless bacteria. Misregulated responses can lead t...

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Detalhes bibliográficos
Main Authors: Chang, Pamela V., Hao, Liming, Offermanns, Stefan, Medzhitov, Ruslan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926023/
https://ncbi.nlm.nih.gov/pubmed/24390544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1322269111
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