Targeting the ERK pathway reduces liver metastasis of Smad4-inactivated colorectal cancer

Transforming growth factor β (TGF-β)/Smad signaling is involved in colorectal carcinoma (CRC) development and progression. The frequent loss of SMAD4 is associated with liver metastasis and poor prognosis of CRC, but the underlying mechanism remains elusive. This study aimed to elucidate the role of...

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Detalhes bibliográficos
Main Authors: Ai, Xi, Wu, Yanhui, Zhang, Wei, Zhang, Zhanguo, Jin, Guannan, Zhao, Jianping, Yu, Jingjing, Lin, Youzhi, Zhang, Wanguang, Liang, Huifang, Datta, Pran K, Zhang, Mingzhi, Zhang, Bixiang, Chen, Xiaoping
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3925661/
https://ncbi.nlm.nih.gov/pubmed/24025354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.26427
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