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Anti-metastatic Role of Smad4 Signaling in Colorectal Cancer
BACKGROUND & AIMS: Transforming growth factor (TGF)-β signaling occurs through Smads 2/3/4, which translocate to the nucleus to regulate transcription; TGF-β has tumor suppressive effects in some tumor models and pro-metastatic effects in others. In patients with colorectal cancer (CRC), mutatio...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2831103/ https://ncbi.nlm.nih.gov/pubmed/19909744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2009.11.004 |
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