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Effects of a second-generation human anti-ErbB2 ImmunoRNase on trastuzumab-resistant tumors and cardiac cells

The inhibition of ErbB2 by the use of human antibodies can be a valuable strategy for the treatment of breast and gastric cancer. Trastuzumab, a humanized anti-ErbB2 antibody in clinical use, is effective but can engender resistance as well as cardiotoxicity. ImmunoRNases, made up of a human anti-Er...

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Sonraí Bibleagrafaíochta
Main Authors: D'Avino, Chiara, Paciello, Rolando, Riccio, Gennaro, Coppola, Melina, Laccetti, Paolo, Maurea, Nicola, Raines, Ronald T., De Lorenzo, Claudia
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3925340/
https://ncbi.nlm.nih.gov/pubmed/24421342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzt065
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