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A novel fully human antitumor ImmunoRNase resistant to the RNase inhibitor
The ErbB2 tyrosine kinase receptor is an attractive target for immunotherapy, as it is overexpressed in many carcinomas. ImmunoRNases, made up of a human anti-ErbB2 scFv (single chain antibody fragment) and human RNases, have been engineered to overcome the limits of immunotoxins, made up of mouse a...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3572756/ https://ncbi.nlm.nih.gov/pubmed/23232187 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzs101 |
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