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A novel fully human antitumor ImmunoRNase resistant to the RNase inhibitor

The ErbB2 tyrosine kinase receptor is an attractive target for immunotherapy, as it is overexpressed in many carcinomas. ImmunoRNases, made up of a human anti-ErbB2 scFv (single chain antibody fragment) and human RNases, have been engineered to overcome the limits of immunotoxins, made up of mouse a...

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Hlavní autoři: Riccio, Gennaro, D'Avino, Chiara, Raines, Ronald T., De Lorenzo, Claudia
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572756/
https://ncbi.nlm.nih.gov/pubmed/23232187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzs101
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