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A novel fully human antitumor ImmunoRNase resistant to the RNase inhibitor

The ErbB2 tyrosine kinase receptor is an attractive target for immunotherapy, as it is overexpressed in many carcinomas. ImmunoRNases, made up of a human anti-ErbB2 scFv (single chain antibody fragment) and human RNases, have been engineered to overcome the limits of immunotoxins, made up of mouse a...

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Main Authors: Riccio, Gennaro, D'Avino, Chiara, Raines, Ronald T., De Lorenzo, Claudia
格式: Artigo
語言:Inglês
出版: Oxford University Press 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572756/
https://ncbi.nlm.nih.gov/pubmed/23232187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzs101
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