Human bronchus-mediated mutagenesis of mammalian cells by carcinogenic polynuclear aromatic hydrocarbons.

Cultured human bronchial explants activated benzo[alpha]pyrene (BzaP) into electrophilic metabolites that bind to DNA in bronchial epithelial cells. Promutagenic and mutagenic metabolites of BzaP were also released into the culture medium. An increase in mutation frequency for ouabain resistance was...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Hsu, I C, Stoner, G D, Autrup, H, Trump, B F, Selkirk, J K, Harris, C C
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1978
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC392471/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/148049/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.75.4.2003
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