Human bronchus-mediated mutagenesis of mammalian cells by carcinogenic polynuclear aromatic hydrocarbons.

Cultured human bronchial explants activated benzo[alpha]pyrene (BzaP) into electrophilic metabolites that bind to DNA in bronchial epithelial cells. Promutagenic and mutagenic metabolites of BzaP were also released into the culture medium. An increase in mutation frequency for ouabain resistance was...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Hsu, I C, Stoner, G D, Autrup, H, Trump, B F, Selkirk, J K, Harris, C C
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1978
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC392471/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/148049/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.75.4.2003
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