Human bronchus-mediated mutagenesis of mammalian cells by carcinogenic polynuclear aromatic hydrocarbons.

Cultured human bronchial explants activated benzo[alpha]pyrene (BzaP) into electrophilic metabolites that bind to DNA in bronchial epithelial cells. Promutagenic and mutagenic metabolites of BzaP were also released into the culture medium. An increase in mutation frequency for ouabain resistance was...

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Dades bibliogràfiques

Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Hsu, I C, Stoner, G D, Autrup, H, Trump, B F, Selkirk, J K, Harris, C C
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1978
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC392471/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/148049/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.75.4.2003
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