X-Aptamers: A bead-based selection method for random incorporation of drug-like moieties onto next-generation aptamers for enhanced binding

By combining pseudo-random bead-based aptamer libraries with conjugation chemistry, we have created next-generation aptamers, X-aptamers (XAs). Several X ligands can be added in a directed or random fashion to the aptamers to further enhance their binding affinities to the target proteins. Here we d...

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Hauptverfasser: He, Weiguo, Elizondo-Riojas, Miguel-Angel, Li, Xin, Lokesh, Ganesh Lakshmana Rao, Somasunderam, Anoma, Thiviyanathan, Varatharasa, Volk, David E., Durland, Ross H., Englehardt, Johnnie, Cavasotto, Claudio N., Gorenstein, David G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924539/
https://ncbi.nlm.nih.gov/pubmed/23057694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300471d
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