Drosophila TRPML Forms PI(3,5)P(2)-activated Cation Channels in Both Endolysosomes and Plasma Membrane

Transient Receptor Potential mucolipin (TRPML) channels are implicated in endolysosomal trafficking, lysosomal Ca(2+) and Fe(2+) release, lysosomal biogenesis, and autophagy. Mutations in human TRPML1 cause the lysosome storage disease, mucolipidosis type IV (MLIV). Unlike vertebrates, which express...

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Dettagli Bibliografici
Autori principali: Feng, Xinghua, Huang, Yu, Lu, Yungang, Xiong, Jian, Wong, Ching-On, Yang, Pu, Xia, Jintang, Chen, De, Du, Guangwei, Venkatachalam, Kartik, Xia, Xuefeng, Zhu, Michael X.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924289/
https://ncbi.nlm.nih.gov/pubmed/24375408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.506501
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