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Differential mechanisms of action of the mucolipin synthetic agonist, ML-SA1, on insect TRPML and mammalian TRPML1
Mucolipin synthetic agonist 1 (ML-SA1) was recently identified to activate mammalian TRPML channels and shown to alleviate lipid accumulation in lysosomes of cellular models of lysosome storage diseases, mucolipidosis type IV (MLIV) and Niemann-Pick’s disease type C (NPC). Owning to its potential us...
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| Publicado no: | Cell Calcium |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4252876/ https://ncbi.nlm.nih.gov/pubmed/25266962 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceca.2014.09.004 |
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