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Drosophila TRPML is Required For TORC1 Activation

Loss-of-function mutations in TRPML1 (Transient Receptor Potential Mucolipin 1) cause a lysosomal storage disorder called mucolipidosis type IV (MLIV). Previously, we established a Drosophila model for MLIV by knocking out the single TRPML1 homolog expressed in flies [1]. The mutant animals displaye...

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Detalhes bibliográficos
Main Authors: Wong, Ching-On, Li, Ruoxia, Montell, Craig, Venkatachalam, Kartik
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443270/
https://ncbi.nlm.nih.gov/pubmed/22863314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2012.06.055
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