The ZEB1 Transcription Factor Acts in a Negative Feedback Loop with miR200 Downstream of Ras and Rb1 to Regulate Bmi1 Expression

Ras mutations are frequent in cancer cells where they drive proliferation and resistance to apoptosis. However in primary cells, mutant Ras instead can cause oncogene-induced senescence, a tumor suppressor function linked to repression of the polycomb factor Bmi1, which normally regulates cell cycle...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Liu, Yongqing, Sánchez-Tilló, Ester, Lu, Xiaoqin, Huang, Li, Clem, Brian, Telang, Sucheta, Jenson, Alfred B., Cuatrecasas, Miriam, Chesney, Jason, Postigo, Antonio, Dean, Douglas C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2014
Aiheet:
Molecular Bases of Disease
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924277/
https://ncbi.nlm.nih.gov/pubmed/24371144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.533505
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