Sequential Inductions of the ZEB1 Transcription Factor Caused by Mutation of Rb and Then Ras Proteins Are Required for Tumor Initiation and Progression

Rb1 restricts cell cycle progression, and it imposes cell contact inhibition to suppress tumor outgrowth. It also triggers oncogene-induced senescence to block Ras mutation. Loss of the Rb1 pathway, which is a hallmark of cancer cells, then provides a permissive environment for Ras mutation, and Ras...

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Detalhes bibliográficos
Main Authors: Liu, Yongqing, Sánchez-Tilló, Ester, Lu, Xiaoqin, Huang, Li, Clem, Brian, Telang, Sucheta, Jenson, Alfred B., Cuatrecasas, Miriam, Chesney, Jason, Postigo, Antonio, Dean, Douglas C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630860/
https://ncbi.nlm.nih.gov/pubmed/23443660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.434951
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