Mouse Fibroblasts Lacking RB1 Function Form Spheres and Undergo Reprogramming to a Cancer Stem Cell Phenotype

Activation of the RB1 pathway triggers the cell-cycle arrest that mediates cell-cell contact inhibition. Accordingly, mutation of all three RB1 family members leads to loss of contact inhibition and outgrowth of fibroblasts into spheres where cell-cell contacts predominate. We present evidence that...

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Autores principales: Liu, Yongqing, Clem, Brian, Zuba-Surma, Ewa K., El-Naggar, Shahenda, Telang, Sucheta, Jenson, Alfred B., Wang, Yali, Shao, Hui, Ratajczak, Mariusz Z., Chesney, Jason, Dean, Douglas C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743858/
https://ncbi.nlm.nih.gov/pubmed/19341623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2009.02.015
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