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Mutations that disrupt Ca(2+)-binding activity endow Doc2β with novel functional properties during synaptic transmission

Double C2-domain protein (Doc2) is a Ca(2+)-binding protein implicated in asynchronous and spontaneous neurotransmitter release. Here we demonstrate that each of its C2 domains senses Ca(2+); moreover, the tethered tandem C2 domains display properties distinct from the isolated domains. We confirm t...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Gaffaney, Jon D., Xue, Renhao, Chapman, Edwin R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The American Society for Cell Biology 2014
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3923640/
https://ncbi.nlm.nih.gov/pubmed/24356452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E13-10-0571
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