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Mutations that disrupt Ca(2+)-binding activity endow Doc2β with novel functional properties during synaptic transmission
Double C2-domain protein (Doc2) is a Ca(2+)-binding protein implicated in asynchronous and spontaneous neurotransmitter release. Here we demonstrate that each of its C2 domains senses Ca(2+); moreover, the tethered tandem C2 domains display properties distinct from the isolated domains. We confirm t...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3923640/ https://ncbi.nlm.nih.gov/pubmed/24356452 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E13-10-0571 |
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