Crystal Structure of Mycoplasma arthritidis Mitogen Complexed with HLA-DR1 Reveals a Novel Superantigen Fold and a Dimerized Superantigen-MHC Complex

Mycoplasma arthritidis -derived mitogen (MAM) is a superantigen that can activate large fractions of T cells bearing particular TCR Vβ elements. Here we report the crystal structure of MAM complexed with a major histocompatibility complex (MHC) antigen, HLA-DR1, loaded with haemagglutinin peptide 30...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Zhao, Yiwei, Li, Zhong, Drozd, Sandra J., Guo, Yi, Mourad, Walid, Li, Hongmin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2004
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3923524/
https://ncbi.nlm.nih.gov/pubmed/14962388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2004.01.008
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