Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities

In glioblastoma, PI3kinase (PI3K) signaling is frequently activated by loss of the tumor suppressor PTEN(1). However, it is not known whether inhibiting PI3K represents a selective and effective approach for treatment. Here we interrogate large databases and find that Shh signaling is activated in P...

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Main Authors: Gruber-Filbin, Mariella, Dabral, Sukriti K., Pazyra-Murphy, Maria F., Ramkissoon, Shakti, Kung, Andrew L., Pak, Ekaterina, Chung, Jarom, Theisen, Matthew A., Sun, Yanping, Franchetti, Yoko, Sun, Yu, Shulman, David S., Redjal, Navid, Tabak, Barbara, Beroukhim, Rameen, Wang, Qi, Zhao, Jean, Dorsch, Marion, Buonamici, Silvia, Ligon, Keith L., Kelleher, Joseph F., Segal, Rosalind A.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3923315/
https://ncbi.nlm.nih.gov/pubmed/24076665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3328
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