Structural basis of stereospecific reduction by quinuclidinone reductase

Chiral molecule (R)-3-quinuclidinol, a valuable compound for the production of various pharmaceuticals, is efficiently synthesized from 3-quinuclidinone by using NADPH-dependent 3-quinuclidinone reductase (RrQR) from Rhodotorula rubra. Here, we report the crystal structure of RrQR and the structure-...

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Autori principali: Takeshita, Daijiro, Kataoka, Michihiko, Miyakawa, Takuya, Miyazono, Ken-ichi, Kumashiro, Shoko, Nagai, Takahiro, Urano, Nobuyuki, Uzura, Atsuko, Nagata, Koji, Shimizu, Sakayu, Tanokura, Masaru
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer 2014
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3922912/
https://ncbi.nlm.nih.gov/pubmed/24507746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2191-0855-4-6
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