Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch

A clear relationship exists between visceral obesity and type 2 diabetes, whereas subcutaneous obesity is comparatively benign. Here we show that adipocyte-specific deletion of the coregulatory protein PRDM16 caused minimal effects on classical brown fat but markedly inhibited beige adipocyte functi...

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Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Cohen, Paul, Levy, Julia D., Zhang, Yingying, Frontini, Andrea, Kolodin, Dmitriy P., Svensson, Katrin J., Lo, James C., Zeng, Xing, Ye, Li, Khandekar, Melin J., Wu, Jun, Gunawardana, Subhadra C., Banks, Alexander S., Camporez, João Paulo G., Jurczak, Michael J., Kajimura, Shingo, Piston, David W., Mathis, Diane, Cinti, Saverio, Shulman, Gerald I., Seale, Patrick, Spiegelman, Bruce M.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2014
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3922400/
https://ncbi.nlm.nih.gov/pubmed/24439384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.12.021
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