Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch

A clear relationship exists between visceral obesity and type 2 diabetes, whereas subcutaneous obesity is comparatively benign. Here we show that adipocyte-specific deletion of the coregulatory protein PRDM16 caused minimal effects on classical brown fat but markedly inhibited beige adipocyte functi...

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Main Authors: Cohen, Paul, Levy, Julia D., Zhang, Yingying, Frontini, Andrea, Kolodin, Dmitriy P., Svensson, Katrin J., Lo, James C., Zeng, Xing, Ye, Li, Khandekar, Melin J., Wu, Jun, Gunawardana, Subhadra C., Banks, Alexander S., Camporez, João Paulo G., Jurczak, Michael J., Kajimura, Shingo, Piston, David W., Mathis, Diane, Cinti, Saverio, Shulman, Gerald I., Seale, Patrick, Spiegelman, Bruce M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3922400/
https://ncbi.nlm.nih.gov/pubmed/24439384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.12.021
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