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Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells.

The effect of the tumor-promoting agent phorbol 12-myristate 13-acetate (PMA) on insulin receptors and insulin action was studied in rat hepatoma cells in culture. PMA (0.1-1.0 micrograms/ml) did not affect insulin binding either acutely or chronically but inhibited insulin stimulation of glycogen s...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Takayama, S, White, M F, Lauris, V, Kahn, C R
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1984
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC392239/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6393128/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.24.7797
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