Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells.
The effect of the tumor-promoting agent phorbol 12-myristate 13-acetate (PMA) on insulin receptors and insulin action was studied in rat hepatoma cells in culture. PMA (0.1-1.0 micrograms/ml) did not affect insulin binding either acutely or chronically but inhibited insulin stimulation of glycogen s...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1984
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC392239/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6393128/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.24.7797 |
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