Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells.

The effect of the tumor-promoting agent phorbol 12-myristate 13-acetate (PMA) on insulin receptors and insulin action was studied in rat hepatoma cells in culture. PMA (0.1-1.0 micrograms/ml) did not affect insulin binding either acutely or chronically but inhibited insulin stimulation of glycogen s...

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Bibliographic Details
Main Authors: Takayama, S, White, M F, Lauris, V, Kahn, C R
Format: Artigo
Language:Inglês
Published: 1984
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC392239/
https://ncbi.nlm.nih.gov/pubmed/6393128
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