Protein kinase C phosphorylates topoisomerase II: topoisomerase activation and its possible role in phorbol ester-induced differentiation of HL-60 cells.

DNA topoisomerase II from Drosophila was phosphorylated effectively by protein kinase C. With a Km of about 100 nM, the reaction was rapid, occurring at 4 degrees C as well as at 30 degrees C and requiring as little as 0.6 ng of the protein kinase per 170 ng of topoisomerase. About 0.85 mol of phosp...

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Detalhes bibliográficos
Main Authors: Sahyoun, N, Wolf, M, Besterman, J, Hsieh, T, Sander, M, LeVine, H, Chang, K J, Cuatrecasas, P
Formato: Artigo
Idioma:Inglês
Publicado em: 1986
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC323131/
https://ncbi.nlm.nih.gov/pubmed/3006058
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