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Modelling clinical data shows active tissue concentration of daclatasvir is 10-fold lower than its plasma concentration
OBJECTIVES: Daclatasvir is a highly potent inhibitor of hepatitis C virus. We estimated the active tissue concentration of daclatasvir in vivo. METHODS: We developed a mathematical model incorporating pharmacokinetic/pharmacodynamic and viral dynamics. By fitting the model to clinical data reported...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3922152/ https://ncbi.nlm.nih.gov/pubmed/24169581 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkt423 |
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