Population Pharmacokinetic Study of Benznidazole in Pediatric Chagas Disease Suggests Efficacy despite Lower Plasma Concentrations than in Adults

INTRODUCTION: Chagas disease, caused by the parasite Trypanosoma cruzi, can lead to long term cardiac morbidity. Treatment of children with benznidazole is effective, but no pediatric pharmacokinetics data are available and clinical pharmacology information on the drug is scarce. PATIENTS AND METHOD...

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Bibliografski detalji
Glavni autori: Altcheh, Jaime, Moscatelli, Guillermo, Mastrantonio, Guido, Moroni, Samanta, Giglio, Norberto, Marson, Maria Elena, Ballering, Griselda, Bisio, Margarita, Koren, Gideon, García-Bournissen, Facundo
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
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Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031103/
https://ncbi.nlm.nih.gov/pubmed/24853169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002907
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