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Atrial natriuretic factor elicits an endothelium-independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle.

A 26 amino acid synthetic peptide fragment of atrial natriuretic factor (ANF) relaxed isolated rabbit aortic segments in which the endothelium was either intact or functionally destroyed. The relaxations were temporally associated with increases in levels of cGMP with no change in the levels of cAMP...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Winquist, R J, Faison, E P, Waldman, S A, Schwartz, K, Murad, F, Rapoport, R M
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1984
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC392208/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6150486/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.23.7661
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