The CNS-Penetrant Soluble Guanylate Cyclase Stimulator CY6463 Reveals its Therapeutic Potential in Neurodegenerative Diseases

Effective treatments for neurodegenerative diseases remain elusive and are critically needed since the burden of these diseases increases across an aging global population. Nitric oxide (NO) is a gasotransmitter that binds to soluble guanylate cyclase (sGC) to produce cyclic guanosine monophosphate...

Descripció completa

Dades bibliogràfiques

Autors principals:	Susana S. Correia, Rajesh R. Iyengar, Peter Germano, Kim Tang, Sylvie G. Bernier, Chad D. Schwartzkopf, Jenny Tobin, Thomas W.-H. Lee, Guang Liu, Sarah Jacobson, Andrew Carvalho, Glen R. Rennie, Joon Jung, Paul A. Renhowe, Elisabeth Lonie, Christopher J. Winrow, John R. Hadcock, Juli E. Jones, Mark G. Currie
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2021-05-01
Col·lecció:	Frontiers in Pharmacology
Matèries:	cGMP (cyclic GMP) nitric oxide soluble guanylate cyclase (sGC) neurodegeneration neuroprotection
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fphar.2021.656561/full
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!