Selective CDK9 inhibition overcomes TRAIL resistance by concomitant suppression of cFlip and Mcl-1

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can induce apoptosis in many cancer cells without causing toxicity in vivo. However, to date, TRAIL-receptor agonists have only shown limited therapeutic benefit in clinical trials. This can, most likely, be attributed to the fact that...

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Detalhes bibliográficos
Main Authors: Lemke, J, von Karstedt, S, Abd El Hay, M, Conti, A, Arce, F, Montinaro, A, Papenfuss, K, El-Bahrawy, M A, Walczak, H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3921597/
https://ncbi.nlm.nih.gov/pubmed/24362439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.179
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