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Loss of MeCP2 From Forebrain Excitatory Neurons Leads to Cortical Hyperexcitation and Seizures

Mutations of MECP2 cause Rett syndrome (RTT), a neurodevelopmental disorder leading to loss of motor and cognitive functions, impaired social interactions, and seizure at young ages. Defects of neuronal circuit development and function are thought to be responsible for the symptoms of RTT. The major...

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Detalhes bibliográficos
Main Authors: Zhang, Wen, Peterson, Matthew, Beyer, Barbara, Frankel, Wayne N., Zhang, Zhong-wei
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3921436/
https://ncbi.nlm.nih.gov/pubmed/24523563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4900-12.2014
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